Cayman 5-Bromouridine 5-Triphosphate (Sodium Salt); Purity- Grea

Olprinone is an inhibitor of phosphodiesterase 3 (PDE3; IC₅₀ = 0.35 μM for human cardiac enzyme). It is selective for PDE3 over PDE1 and PDE2 (IC₅₀s = 150 and 100 μM, respectively). Olprinone induces relaxation of precontracted isolated rabbit renal and carotid arterial rings (IC₅₀s = 40 and 103 nM, respectively). It reduces infarct size and improves cardiac function in a rat model of myocardial ischemia-reperfusion injury when administered at a dose of 0.6 mg/kg twice per day. Olprinone (0.2 mg/kg) reduces cortical and striatal damage, as well as reduces injured cerebral tissue nitrotyrosine formation, apoptosis, and levels of inducible nitric oxide synthase (iNOS), IL-1β, and intercellular adhesion molecule 1 (ICAM-1) in a rat model of cerebral ischemia-reperfusion injury. It inhibits neutrophil infiltration into the lungs and inhibits increases in serum levels of TNF-α and IL-6 in a rat model of LPS-induced lung inflammation when administered at a dose of 0.2 mg/kg.

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