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Cayman 7-Methylguanine; Purity- Greater Than Or Equal To 98%; Siz
List Price
$121.00
Your Price
$121.00
Cayman 7-Methylguanine; Purity- Greater Than Or Equal To 98%; Size- 250 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-18161-250
MFG.PART:
18161-250
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Brimonidine is an agonist of α2-adrenergic receptors (α2-ARs; Kis = 2.7, 52, and 44 nM for α2A, α2B, and α2C-ARs, respectively, in CHO cells). It is selective for α2-ARs over α1-ARs (Ki = 1,800 nM in human brain). Brimonidine lowers intraocular pressure in DBA/2J mice, a model of glaucoma, to control levels when applied topically to the eye as a 0.1% solution. It also inhibits glutamate release, prevents upregulation of NMDA receptors containing NR1 and NR2A subunits, and protects rat retinal ganglion cells against glutamate excitotoxicity in a rat model of retinal ischemia when administered at a dose of 1 mg/kg per day. Formulations containing brimonidine have been used in the treatment of open-angle glaucoma and ocular hypertension.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-
CAS Number
70359-46-5
Synonyms
- AGN 190342LF
- Alphagan P
Molecular Formula
C11H10BrN5 • C4H6O6
Formula Weight
442.2
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMSO: 1 mg/ml
- PBS (pH 7.2): 3 mg/ml
λmax
244, 320 nm
SMILES
BrC1=C(NC2=NCCN2)C=CC3=C1N=CC=N3.O[C@H]([C@@H](O)C(O)=O)C(O)=O
InChi Code
InChI=1S/C11H10BrN5.C4H6O6/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8;5-1(3(7)8)2(6)4(9)10/h1-4H,5-6H2,(H2,15,16,17);1-2,5-6H,(H,7,8)(H,9,10)
InChi Key
QZHBYNSSDLTCRG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18161-250 |
|---|---|
| Featured | No |
| Supplier Part Number | 18161-250 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 578-76-7 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |