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Cayman Nifuroxazide
List Price
$268.00
Your Price
$268.00
Cayman Nifuroxazide - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-18163-1
MFG.PART:
18163-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Nifuroxazide is a nitrofuran antibiotic. It is active against strains of the enteropathogenic bacteria C. jejuni, Salmonella, Y. enterocolitica, Shigella, and E. coli. It inhibits quorum sensing and virulence factor production in P. aeruginosa. Nifuroxazide inhibits STAT3 activity in a reporter assay (IC50 = ~3 µM) and decreases viability of U266 and INA-6 myeloma cells, which have constitutive STAT3 phosphorylation, with EC50 values of approximately 4.5 µM for both. It also decreases viability, migration, and invasion of, and induces apoptosis in, MCF-7, 4T1, and MDA-MB-231 breast cancer cells. Nifuroxazide (50 mg/kg per day) reduces tumor growth and prevents pulmonary metastasis in a 4T1 murine mammary carcinoma model. It also reduces diarrhea, weight loss, and colon inflammation in a rat model of acetic acid-induced ulcerative colitis.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-hydroxy-
CAS Number
965-52-6
Molecular Formula
C12H9N3O5
Formula Weight
275.2
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH7.2) (1:1): 0.5 mg/mL
λmax
285, 365 nm
SMILES
OC1=CC=C(C(N/N=C/C2=CC=C([N+]([O-])=O)O2)=O)C=C1
InChi Code
InChI=1S/C12H9N3O5/c16-9-3-1-8(2-4-9)12(17)14-13-7-10-5-6-11(20-10)15(18)19/h1-7,16H,(H,14,17)/b13-7+
InChi Key
YCWSUKQGVSGXJO-NTUHNPAUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18163-1 |
|---|---|
| Supplier Part Number | 18163-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 965-52-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |