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Cayman Syk Inhibitor II
List Price $251.00 Your Price $251.00
Cayman Syk Inhibitor II - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-18202-1
MFG.PART: 18202-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs and mediates downstream signaling. Syk inhibitor II is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks Syk (IC50 = 41 nM) in an ATP-competitive manner. It is much less potent against PKCε, PKCβII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 µM, respectively). Syk inhibitor II has been shown to prevent FcεRI-mediated 5-HT release in RBL-2H3 cells in vitro (IC50 = 460 nM) and to inhibit passive cutaneous anaphylaxis reactions in mice (ID50 = 13.2 mg/kg, s.c.).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[(2-aminoethyl)
CAS Number
726695-51-8
Synonyms
- Spleen Tyrosine Kinase Inhibitor II
Molecular Formula
C14H15F3N6O
Formula Weight
340.3
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 25 mg/mL
- DMSO: 15 mg/mL
λmax
260, 284 nm
SMILES
NCCNC1=NC(NC2=CC(C(F)(F)F)=CC=C2)=C(C(N)=O)C=N1
InChi Code
InChI=1S/C14H15F3N6O/c15-14(16,17)8-2-1-3-9(6-8)22-12-10(11(19)24)7-21-13(23-12)20-5-4-18/h1-3,6-7H,4-5,18H2,(H2,19,24)(H2,20,21,22,23)
InChi Key
FQNFLNSVHWCZML-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-18202-1 |
|---|---|
| Supplier Part Number | 18202-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 726695-51-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |