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Cayman N-Desmethyl Sildenafil; Purity- Greater Than Or Equal To 9
List Price
$29.00
Your Price
$29.00
Cayman N-Desmethyl Sildenafil; Purity- Greater Than Or Equal To 98%; Size- 1 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-18208-1
MFG.PART:
18208-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
URMC-099 is an orally bioavailable, brain-penetrant inhibitor of mixed-lineage kinases (MLKs) with IC50 values of 19, 42, 14, and 150 nM for MLK1, MLK2, MLK3, and the related MLK family member DLK, respectively. It also inhibits LRRK2 activity with an IC50 value of 11 nM. In vitro, URMC-099 has been shown to reduce inflammatory cytokine production by HIV-1 Tat-exposed microglia and to prevent destruction and phagocytosis of cultured neuronal axons by these cells. In rodent models of HIV-associated neurocognitive disorders, URMC-099 demonstrates anti-inflammatory and neuroprotective effects.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3-(1H-indol-5-yl)-5-[4-[(4-methyl-1-
CAS Number
1229582-33-5
Molecular Formula
C27H27N5
Formula Weight
421.5
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 25 mg/ml
- DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml
- DMSO: 25 mg/ml
- Ethanol: 1 mg/ml
λmax
211, 244, 267 nm
SMILES
CN1CCN(CC2=CC=C(C3=CC(C(C4=CC=C(NC=C5)C5=C4)=CN6)=C6N=C3)C=C2)CC1
InChi Code
InChI=1S/C27H27N5/c1-31-10-12-32(13-11-31)18-19-2-4-20(5-3-19)23-15-24-25(17-30-27(24)29-16-23)21-6-7-26-22(14-21)8-9-28-26/h2-9,14-17,28H,10-13,18H2,1H3,(H,29,30)
InChi Key
QKKIWEILHCXECO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18208-1 |
|---|---|
| Featured | No |
| Supplier Part Number | 18208-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 139755-82-1 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |