Cayman 7-Diethylamino-3-(4-Maleimidophenyl)-4-Methylcoumarin; Pur

Violacein is a bacterial metabolite originally isolated from C. violaceum that has antibacterial and antiprotozoal activities.^, It is produced by C. violaceum as a purple pigment in response to N-hexanoyl homoserine lactone (Item No. ), a property that has been modified to create a strain of C. violaceum used in detecting quorum-sensing molecules. Violacein is active against Gram-positive bacteria, including B. subtilis and S. aureus (MICs = 0.8 and 1.6 µM, respectively). It is also active against P. falciparum, including chloroquine-susceptible and -resistant strains (IC₅₀s = 0.85 and 0.63 µM, respectively). It reduces parasitemia in a mouse model of nonlethal P. chabaudi chabaudi infection when administered at a dose of 7.5 mg/kg and increases survival in a mouse model of lethal P. chabaudi chabaudi infection. Violacein permeabilizes the cytoplasmic membrane of bacterial cells but does not affect the cell wall.

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