Cayman 5-Cis Carbaprostacyclin; Purity- Greater Than Or Equal To

CBL0137 is a metabolically stable curaxin that activates p53 with an EC₅₀ value of 0.37 µM and inhibits NF-κB with an EC₅₀ of 0.47 µM. It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-κB and promoting cancer cell death. CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates efficacy of gemcitabine (Item No. ) in preclinical models of pancreatic cancer.^,

WARNING This product is not for human or veterinary use.