Cayman Prostaglandin I2 (Sodium Salt); Purity- Greater Than Or Eq

PB 28 is a sigma (σ) receptor ligand that binds to σ₁ and σ₂ receptors (K_is = 13 and 0.28 nM, respectively, in MCF-7 cell membranes) with anticancer and antiviral activities.^, It is selective for σ₁ and σ₂ receptors over human ether-a-go-go (hERG) channels (K_i = 1,000 nM). PB 28 inhibits growth of MCF-7 and multidrug-resistant MCF-7/adr cells (IC₅₀s = 25 and 15 nM, respectively). It also decreases basal P-glycoprotein (P-gp) levels in the same cells. PB 28 reduces severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectivity in Vero E6 cells (IC₉₀ = 278 nM), which is 20 times more potent than hydroxychloroquine (Item No. ).

WARNING This product is not for human or veterinary use.