We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Cayman Ciclesonide; Purity- Greater Than Or Equal To 98%; Size- 1
List Price
$184.00
Your Price
$184.00
Cayman Ciclesonide; Purity- Greater Than Or Equal To 98%; Size- 10 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-18227-10
MFG.PART:
18227-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Ciclesonide (CIC) is a prodrug form of the glucocorticoid receptor agonist desisobutyryl-CIC (des-CIC).1 CIC binds to the glucocorticoid receptor with a Ki value of 37 nM.2 It is selective for the glucocorticoid receptor over the estrogen, progesterone, and testosterone receptors. CIC inhibits eosinophil influx into the lung (ED50 = 0.49 mg/kg) and reduces sephadex-induced lung edema (ED50 = 0.72 mg/kg) in a rat model of ovalbumin-sensitized and -challenged airway inflammation. Formulations containing CIC have been used in the maintenance treatment of asthma and in the treatment of allergic rhinitis.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
16α,17-[[(R)-
CAS Number
126544-47-6
Synonyms
- CIC
- RPR 251526
Molecular Formula
C32H44O7
Formula Weight
540.7
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 20 mg/ml
- DMSO: 25 mg/ml
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
- Ethanol: 10 mg/ml
λmax
243 nm
SMILES
O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@]5([H])[C@@]4(C(COC(C(C)C)=O)=O)O[C@H](C6CCCCC6)O5)=C1
InChi Code
InChI=1S/C32H44O7/c1-18(2)28(36)37-17-25(35)32-26(38-29(39-32)19-8-6-5-7-9-19)15-23-22-11-10-20-14-21(33)12-13-30(20,3)27(22)24(34)16-31(23,32)4/h12-14,18-19,22-24,26-27,29,34H,5-11,15-17H2,1-4H3/t22-,23-,24-,26+,27+,29+,30-,31-,32+/m0/s1
InChi Key
LUKZNWIVRBCLON-GXOBDPJESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18227-10 |
|---|---|
| Featured | No |
| Supplier Part Number | 18227-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 126544-47-6 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |