Cayman Aspirin-D4; Purity- Greater Than Or Equal To 95%; Size- 1

Aspirin-d₄ is intended for use as an internal standard for the quantification of aspirin (Item No. ) by GC- or LC-MS. Aspirin is a non-steroidal anti-inflammatory drug (NSAID) and a covalent inhibitor of COX-1 and COX-2 (IC₅₀s = 4.45 and 13.88 µM, respectively, for the human enzymes). It is also an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS; IC₅₀ = 750 µM for the ovine enzyme). Aspirin (6 µg/ml) inhibits epinephrine- and ADP-induced platelet aggregation. In vivo, aspirin (30 mg/kg) reduces infarct volume and microglial infiltration in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO). It decreases macrophage infiltration into, increases the number of smooth muscle cells and levels of collagen in, and reduces the area of, atherosclerotic lesions in LDL receptor-deficient mice fed a high-fat diet when administered in the drinking water at 30 mg/L. Formulations containing aspirin have been used in the treatment of pain, fever, and in stroke prevention.

WARNING This product is not for human or veterinary use.