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Cayman Fluoxetine-D5 (Hydrochloride); Purity- Greater Than Or Equ
List Price
$632.00
Your Price
$632.00
Cayman Fluoxetine-D5 (Hydrochloride); Purity- Greater Than Or Equal To 99% Deuterated Forms (D1-D5); Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-18253-5
MFG.PART:
18253-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
RS 127445 is an orally bioavailable and potent antagonist of the serotonin (5-HT) receptor subtype 5-HT2B (Ki = 0.32 nM). It is selective for 5-HT2B over other 5-HT receptor subtypes (Ki = >3 μM for 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C, 5-HT3, 5-HT5, and 5-HT6). RS 127445 reduces contraction of rat isolated stomach fundus (pA2 = 9.5) and lowers intracellular increases in calcium (IC50 = 0.04 nM) induced by 5-HT (Item No. ). It also blocks (±)-α-methyl-5-HT-induced relaxation of isolated rat jugular veins (pA2 = 9.95). RS 127445 (1-30 mg/kg) reduces peristaltic frequency and fecal output in mice in a dose-dependent manner. Systemic administration of RS 127445 (0.16 mg/kg) reduces basal, but not cocaine-induced, dopamine outflow in the nucleus accumbens of rats and decreases hyperlocomotion induced by cocaine (Item Nos. | | ) or quinpirole.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-(4-fluoro-1
CAS Number
199864-86-3
Molecular Formula
C17H16FN3 • HCl
Formula Weight
317.8
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- Ethanol: 30 mg/ml
- Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
223, 309 nm
SMILES
FC1=CC=C(C2=CC(C(C)C)=NC(N)=N2)C3=C1C=CC=C3.Cl
InChi Code
InChI=1S/C17H16FN3.ClH/c1-10(2)15-9-16(21-17(19)20-15)13-7-8-14(18)12-6-4-3-5-11(12)13;/h3-10H,1-2H3,(H2,19,20,21);1H
InChi Key
MKJPYBJBPRFMHL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18253-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 18253-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | Canada |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 1173020-43-3 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |