Cayman Sildenafil-D3; Purity- Greater Than Or Equal To 99% Deuter

2-Cl-IB-MECA is an adenosine A₃ receptor agonist. It binds selectively to adenosine A₃ receptors (K_i = 0.33 nM) over A₁ and A_2A receptors (K_is = 820 and 470 nM, respectively) and inhibits adenylate cyclase activity with an IC₅₀ value of 66.8 nM in CHO cell membranes expressing rat A₃ receptors. 2-Cl-IB-MECA (10 and 100 nM) inhibits proliferation of B16/F10 melanoma cells and increases proliferation of murine bone marrow cells in vitro, effects that can be blocked by the A₃ receptor antagonist MRS1523 (Item No. ). It induces accumulation of cells in the G₀/G₁ phase of the cell cycle and induces apoptosis when used at a concentration of 100 nM. 2-Cl-IB-MECA (6 µg/mg) prevents the development of lung metastatic foci in a B16/F10 mouse model of lung metastasis and reverses decreases in the number of white blood cells and neutrophils induced by cyclophosphamide (Item No. ).

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