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Cayman Incb024360 Analog; Purity- Greater Than Or Equal To 98%; S
List Price
$66.00
Your Price
$66.00
Cayman Incb024360 Analog; Purity- Greater Than Or Equal To 98%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-18265-5
MFG.PART:
18265-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine, leading to the production of NAD+ via the kynurenine pathway. It has been implicated in mediating pathological immunosuppression associated with certain diseases, including cancer. INCB024360 analog is a potent IDO1 inhibitor that demonstrates IC50 values of 67 and 19 nM for human IDO in enzymatic activity and HeLa cell assays, respectively.1,2,3 It is inactive against tryptophan 2,3-dioxygenase (IC50 > 10 µM).2 At 25-75 mg/kg, subcutaneous administration of INCB024360 analog to mice significantly decreased kynurenine levels in plasma and dose-dependently reduced the growth of GM-CSF-secreting B16 tumor xenografts.2 A fluorine-18 moiety has been used to label this compound for use as a probe for imaging IDO1 expression via positron emission tomography.4
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-
CAS Number
914471-09-3
Synonyms
- IDO5L
Molecular Formula
C9H7ClFN5O2
Formula Weight
271.6
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- Ethanol: 30 mg/mL
- Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/mL
λmax
246, 285 nm
SMILES
ON/C(C1=NON=C1N)=N\C2=CC=C(F)C(Cl)=C2
InChi Code
InChI=1S/C9H7ClFN5O2/c10-5-3-4(1-2-6(5)11)13-9(14-17)7-8(12)16-18-15-7/h1-3,17H,(H2,12,16)(H,13,14)
InChi Key
HGXSLPIXNPASGZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18265-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 18265-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 914471-09-3 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |