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Cayman Biib021; Purity- Greater Than Or Equal To 98%; Size- 25 Mg
List Price
$156.00
Your Price
$156.00
Cayman Biib021; Purity- Greater Than Or Equal To 98%; Size- 25 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-18269-25
MFG.PART:
18269-25
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Oclacitinib-13C-d3 is intended for use as an internal standard for the quantification of oclacitinib (Item No. ) by GC- or LC-MS. Oclacitinib is an inhibitor of the JAK family kinases JAK1, JAK2, JAK3, and TYK2 (IC50s = 10, 18, 99, and 84 nM, respectively). It is selective for JAK kinases over a panel of 38 additional kinases at 1 μM. Oclacitinib inhibits LPS-induced increases in IL-12 and TNF-α levels in murine bone marrow-derived dendritic cells (BMDCs) in a concentration-dependent manner. Topical administration of oclacitinib (0.1, 0.25, and 0.5%) reduces scratching behavior and ear edema, as well as decreases levels of IL-1β, IL-4, and IL-6 in ear skin, in a mouse model of allergic dermatitis induced by toluene-2,3-diisocyanate (TDI). Formulations containing oclacitinib have been used in the treatment of pruritus associated with allergic dermatitis and the control of atopic dermatitis in dogs.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
trans-N-
CAS Number
2750534-84-8
Molecular Formula
C14[13C]H20D3N5O2S
Formula Weight
341.5
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility
- DMSO: soluble
- Methanol: soluble
SMILES
CNS(C[C@@H]1CC[C@@H](N(C2=NC=NC3=C2C=CN3)[13C]([2H])([2H])[2H])CC1)(=O)=O
InChi Code
InChI=1S/C15H23N5O2S/c1-16-23(21,22)9-11-3-5-12(6-4-11)20(2)15-13-7-8-17-14(13)18-10-19-15/h7-8,10-12,16H,3-6,9H2,1-2H3,(H,17,18,19)/t11-,12-/i2+1D3
InChi Key
HJWLJNBZVZDLAQ-JWRHSUTGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18269-25 |
|---|---|
| Featured | No |
| Supplier Part Number | 18269-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 848695-25-0 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |