Cayman Ro 20-1724; Purity- Greater Than Or Equal To 95%; Size- 25

PQR530 is a dual inhibitor of PI3Kα and mammalian target of rapamycin (mTOR; IC₅₀s = 11.1 and 7.4 nM, respectively). It inhibits phosphorylation of Akt and ribosomal S6 kinase in A2058 melanoma cells (IC₅₀s = 62.2 and 61.1 nM, respectively). PQR530 inhibits cell growth in a panel of 66 cancer cell lines (mean GI₅₀ = 0.43 µM). In vivo, PQR530 (25 mg/kg) reduces tumor growth in an OVCAR-3 ovarian cancer mouse xenograft model. It decreases the number of seizures per week in a Tsc1^GFAP conditional knockout mouse model of epilepsy.

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