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Cayman Meai (Hydrochloride); Purity- Greater Than Or Equal To 95%
List Price
$356.00
Your Price
$356.00
Cayman Meai (Hydrochloride); Purity- Greater Than Or Equal To 95%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-18286-5
MFG.PART:
18286-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
MK6-83 is an activator of the transient receptor potential cation channel, mucolipin subfamily (TRPML1). TRPML1 is mutated in mucolipidosis type IV (MLIV), a hereditary lysosomal storage disorder characterized by severe delays in intellectual and motor development. MK6-83 increases activity of TRPML1 in lysosomes expressing either wild type or F465L-mutated channels (EC50s = 110 and 100 nM, respectively) and in MLIV patient-derived fibroblasts. It is more effective for F465L mutations than F408Δ (EC50 = 1,230 nM). It also improves zinc trafficking out of lysosomes in F408Δ-expressing fibroblast cells.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-methyl-N-
CAS Number
1062271-24-2
Molecular Formula
C16H20N2O2S2
Formula Weight
336.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:2): 0.33 mg/mL
- Ethanol: 5 mg/mL
SMILES
O=S(NC1=CC=CC=C1N2CCCCC2)(C3=CC=C(C)S3)=O
InChi Code
InChI=1S/C16H20N2O2S2/c1-13-9-10-16(21-13)22(19,20)17-14-7-3-4-8-15(14)18-11-5-2-6-12-18/h3-4,7-10,17H,2,5-6,11-12H2,1H3
InChi Key
IRGYSXZCDAWOOC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-18286-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 18286-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 81593-54-6 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |