Cayman Mocetinostat; Purity- Greater Than Or Equal To 98%; Size-

Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants. Structurally, it is an 18-carbon ω-6 triene isomer of γ-linolenic acid (Item No. ). Jacaric acid induces cell cycle arrest and apoptosis in a variety of cancer cell lines (GI₅₀ = 1-5 µM).^,, It increases the production of reactive oxygen species, and cytotoxicity is abolished by the antioxidant α-tocopherol, suggesting that apoptosis results from oxidative stress.^, Jacaric acid is metabolized in vivo to conjugated linoleic acid (Item No. 90140), which is also cytotoxic to cancer cells. Jacaric acid inhibits cyclooxygenase-1 in vitro (K_i = 1.7 µM) and, with long term feeding, decreases stearoyl-CoA desaturase expression and activity in mice.^,

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