Cayman Mhy908; Purity- Greater Than Or Equal To 98%; Size- 1 Mg;

Fatty acid desaturase 2 (FADS2), also known as Δ⁶-desaturase, is a 444-amino acid transmembrane protein encoded by FADS2. This product is the N-terminal cytoplasmic domain of FADS2, corresponding to residues 2-131 of the full-length sequence. It catalyzes the rate-limiting step in the conversion of the ω-6 and ω-3 precursors linoleic acid (Item Nos. | ) and α-linolenic acid (Item No. ) to their respective long-chain polyunsaturated fatty acids (LC-PUFAs), inserting a cis double bond at position 6 of the fatty acid chain to convert linoleic acid to γ-linolenic acid (Item No. ) and α-linolenic acid to stearidonic acid (Item No. ), respectively. Following secondary desaturation by FADS1 (Item No. ) and chain elongation, FADS2 catalyzes desaturation of 24-carbon LC-PUFA intermediates. FADS2 also catalyzes the desaturation of palmitic acid (Item No. ) to sapienic acid in human sebaceous glands and in various cancer cell lines that express FADS2.^, Hepatic FADS2 protein levels and mRNA expression are increased in mice with high-fat diet-induced obesity and non-alcoholic steatohepatitis (NASH). FADS2 knockout (fads2^-/-) mice are infertile, resistant to obesity, and have altered subcellular membrane diacylglycerol composition which leads to dysregulated post-translational processing of SREBP1c, a key transcription factor in the regulation of lipid metabolism.

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