Cayman Cvt-10216; Purity- Greater Than Or Equal To 98%; Size- 10

Aloperine is an alkaloid found in the roots of S. flavescens with diverse biological activities including antiviral, anticancer, antioxidant, and anti-inflammatory actions.^,,, It inhibits HIV-1 replication and envelope-mediated cell-cell fusion (EC₅₀s = 1.75 and 1.2 μM, respectively) at concentrations well below the cytotoxic concentration (CC₅₀) of >86.5 μM in vitro. Aloperine inhibits the growth of HL-60, U937, and K562 leukemia cell lines with IC₅₀ values of 40, 270, and 360 μM, respectively. Administration of aloperine, at a dose of 60 mg/kg, reduces NOX2, NOX4, superoxide dismutase, and glutathione peroxidase expression in lungs in a rat model of pulmonary hypertension. Topical administration of aloperine reduces ear swelling, ear erythema, and production of inflammatory cytokines TNF-α, IL-1β, and IL-6 in a mouse model of allergic contact dermatitis.

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