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Cayman Cvt-10216; Purity- Greater Than Or Equal To 98%; Size- 5 M
List Price
$118.00
Your Price
$118.00
Cayman Cvt-10216; Purity- Greater Than Or Equal To 98%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-18318-5
MFG.PART:
18318-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme involved in the major oxidative pathway of alcohol metabolism. CVT-10216 is a reversible inhibitor of ALDH2 (IC50 = 29 nM) that demonstrates >40-fold selectivity for ALDH2 over the cytosolic isoform, ALDH1.1 CVT-10216 has been reported to reduce excessive alcohol drinking in alcohol-preferring rats and to prevent self-administration of alcohol in Long-Evans rats.1 This compound has also been shown to produce anxiolytic effects in four different rodent models, including a model of repeated alcohol withdrawal-induced anxiety.1 The efficacy of CVT-10216 has also been examined in rodent models of drug addiction or binge eating of high-fat or high-sugar diets.2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3-[[[3-[4-
CAS Number
1005334-57-5
Synonyms
- GS-455534
Molecular Formula
C24H19NO7S
Formula Weight
465.5
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 25 mg/ml
- DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml
- DMSO: 20 mg/ml
λmax
234, 259 nm
SMILES
OC(C1=CC=CC(COC2=CC=C(C(C(C3=CC=C(NS(C)(=O)=O)C=C3)=CO4)=O)C4=C2)=C1)=O
InChi Code
InChI=1S/C24H19NO7S/c1-33(29,30)25-18-7-5-16(6-8-18)21-14-32-22-12-19(9-10-20(22)23(21)26)31-13-15-3-2-4-17(11-15)24(27)28/h2-12,14,25H,13H2,1H3,(H,27,28)
InChi Key
YYOOFJZTRCPVFD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18318-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 18318-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 1005334-57-5 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |