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Cayman Cox-2 (Ovine Recombinant); Purity- Greater Than Or Equal T
List Price
$820.00
Your Price
$820.00
Cayman Cox-2 (Ovine Recombinant); Purity- Greater Than Or Equal To 80% Estimated By Sds-Page; Size- 5 Kunits; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-18356-5
MFG.PART:
18356-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
DASA-58 is a selective activator of pyruvate kinase M2 (PKM2; AC50 = 38 nM in vitro, EC50 = 19.6 µM in cells). DASA-58 converts PKM2 to a constitutively active enzyme state that is resistant to inhibition by tyrosine-phosphorylated proteins. Through its effects on PKM2, DASA-58 blocks the induction of HIF-1α by lipopolysaccharide in bone marrow-derived macrophages, suppressing the expression of several HIF-1α-dependent targets, including IL-1β. It also impairs metastatic dissemination of prostate cancer PCa cells in SCID mice.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3-
CAS Number
1203494-49-8
Synonyms
- ML-203
- NCGC00185916
Molecular Formula
C19H23N3O6S2
Formula Weight
453.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMSO: 30 mg/ml
λmax
211, 246, 292 nm
SMILES
O=S(N1CCN(S(C2=CC=C(OCCO3)C3=C2)(=O)=O)CCC1)(C4=CC(N)=CC=C4)=O
InChi Code
InChI=1S/C19H23N3O6S2/c20-15-3-1-4-16(13-15)29(23,24)21-7-2-8-22(10-9-21)30(25,26)17-5-6-18-19(14-17)28-12-11-27-18/h1,3-6,13-14H,2,7-12,20H2
InChi Key
GMHIOMMKSMSRLY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18356-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 18356-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -80 |
| Refrigerated-Frozen | Frozen |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |