Cayman Wye-125132; Purity- Greater Than Or Equal To 98%; Size- 1

AZD 3463 is an inhibitor of anaplastic lymphoma kinase (ALK) and the insulin growth factor-1 receptor (IGF-1R). It inhibits ALK with an IC₅₀ value of 15 nM. It inhibits the proliferation of neuroblastoma cells with wild-type (WT) ALK (IC₅₀s = 2.8-21.3 µM) and ALK with the activating mutations ALK^F1174L and ALK^D1091N (IC₅₀s = 1.7 and 16.49 µM, respectively) and induces apoptosis and autophagy. It reduces tumor growth in neuroblastoma mouse xenograft models expressing WT ALK or the ALK^F1174L mutation when administered at a dose of 15 mg/kg per day for 21 days.

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