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Cayman Vidofludimus; Purity- Greater Than Or Equal To 98%; Size-
List Price
$37.00
Your Price
$37.00
Cayman Vidofludimus; Purity- Greater Than Or Equal To 98%; Size- 1 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-18377-1
MFG.PART:
18377-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
LAS191859 is a potent antagonist of CRTH2/DP2 with IC50 values of 9.58, 14, 15.5, and 7.6 nM for recombinant human, rat, mouse, and guinea pig CRTH2/DP2 receptors, respectively. It is selective for CRTH2/DP2 over a panel of 65 enzymes, ion channels, and transporters with <25% inhibition for all targets when tested at a concentration of 10 μM. LAS191859 reduces shape change of eosinophils (IC50s = 2 and 8.2 nM in isolated eosinophils and whole blood, respectively) and eosinophil chemotaxis (IC50 = 1.3 nM) induced by prostaglandin D2 (PGD2; Item No. ) binding to CRTH2/DP2. Oral administration of LAS191859 reduces PGD2-induced systemic eosinophilia in guinea pigs (ID50 = 131 μg/kg).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1-[2-[[(
CAS Number
1420071-13-1
Molecular Formula
C24H24F3N3O3
Formula Weight
459.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/ml
- DMSO: 20 mg/ml
- DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
- Ethanol: 2.5 mg/ml
λmax
272 nm
SMILES
CCN(C(C1CC1)=O)CC2=CC(C(F)(F)F)=CC=C2N3C=C(CC(O)=O)C4=C3N=C(C)C=C4
InChi Code
InChI=1S/C24H24F3N3O3/c1-3-29(23(33)15-5-6-15)12-17-10-18(24(25,26)27)7-9-20(17)30-13-16(11-21(31)32)19-8-4-14(2)28-22(19)30/h4,7-10,13,15H,3,5-6,11-12H2,1-2H3,(H,31,32)
InChi Key
KGBYKYDRYYERIX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-18377-1 |
|---|---|
| Featured | No |
| Supplier Part Number | 18377-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 717824-30-1 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |