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Cayman TCS 5861528
List Price $696.00 Your Price $696.00
Cayman TCS 5861528 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-18380-50
MFG.PART: 18380-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
The transient receptor potential ankyrin 1 (TRPA1) ion channel integrates the nociception and transmission of diverse, potentially damaging and noxious stimuli, including cold, electrophilic compounds, divalent cations, and mechanical stimulation. TCS 5861528 is a selective TRPA1 blocker that antagonizes TRPA1-mediated calcium influx induced by allyl isothiocyanate and 4-hydroxy nonenal (Item No. 32100) with IC50 values of 14.3 and 18.7 μM, respectively.1,2 At 30 mg/kg twice daily in rats, TCS 5861528 has been used to attenuate pain-related behavior in models of diabetic hypersensitivity and postoperative pain.1,3
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1,2,3,6-
CAS Number
332117-28-9
Molecular Formula
C19H23N5O3
Formula Weight
369.4
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMSO: 15 mg/mL
- Ethanol: 0.1 mg/mL
λmax
248 nm
SMILES
CN(C(N1C)=O)C2=C(N(CC(NC3=CC=C(C(CC)C)C=C3)=O)C=N2)C1=O
InChi Code
InChI=1S/C19H23N5O3/c1-5-12(2)13-6-8-14(9-7-13)21-15(25)10-24-11-20-17-16(24)18(26)23(4)19(27)22(17)3/h6-9,11-12H,5,10H2,1-4H3,(H,21,25)
InChi Key
ZUTUWJYMCADJHD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18380-50 |
|---|---|
| Supplier Part Number | 18380-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 332117-28-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |