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Cayman SB-743921 (hydrochloride)
List Price $43.00 Your Price $43.00
Cayman SB-743921 (hydrochloride) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-18384-1
MFG.PART: 18384-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
SB-743921 is a potent inhibitor of the kinesin spindle protein Eg5 (Ki = 0.5 nM for microtubule-stimulated ATPase activity). It inhibits the growth of HCT116 colon, LNCaP and PC3 prostate, K562 leukemia, BxPC-3 pancreas, and NCI-H1299 lung cancer cell lines in vitro (GI50s = 25, 22, 48, 50, 80, and 82 nM, respectively). In vivo, SB-743921 induces complete tumor regression in a COLO 205 mouse xenograft model and partial regression in MCF-7, SK-MES, H69, and OVCAR-3 mouse xenograft models. SB-743921 (2.5-10 mg/kg) also reduces tumor volume in a dose-dependent manner in a diffuse large B cell lymphoma (DLBCL) mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-(3-amino
CAS Number
940929-33-9
Molecular Formula
C31H33ClN2O3 • HCl
Formula Weight
553.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 50 mg/mL
- DMSO: 50 mg/mL
- Ethanol: 20 mg/mL
- PBS (pH 7.2): 0.2 mg/mL
λmax
203, 309 nm
SMILES
ClC1=CC=C(C(C(CC2=CC=CC=C2)=C([C@H](N(C(C3=CC=C(C)C=C3)=O)CCCN)C(C)C)O4)=O)C4=C1.Cl
InChi Code
InChI=1S/C31H33ClN2O3.ClH/c1-20(2)28(34(17-7-16-33)31(36)23-12-10-21(3)11-13-23)30-26(18-22-8-5-4-6-9-22)29(35)25-15-14-24(32)19-27(25)37-30;/h4-6,8-15,19-20,28H,7,16-18,33H2,1-3H3;1H/t28-;/m1./s1
InChi Key
MLMZVWABFOLFGV-LNLSOMNWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18384-1 |
|---|---|
| Supplier Part Number | 18384-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 940929-33-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |