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Cayman CEP-28122
List Price $49.00 Your Price $49.00
Cayman CEP-28122 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-18406-1
MFG.PART: 18406-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
CEP-28122 is a potent inhibitor of anaplastic lymphoma kinase (ALK; IC50 = 1.9 nM) that less potently inhibits other tyrosine and serine/threonine kinases. It blocks the phosphorylation of ALK and other ALK substrates in cells and induces concentration-dependent growth inhibition or cytotoxicity of ALK-positive cancer cells. CEP-28122 is orally active, inhibiting ALK tyrosine phosphorylation in tumor xenografts in mice for more than 12 hours following single oral dosing at 30 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(1S,2S,3R,4R)-3-
CAS Number
1022958-60-6
Molecular Formula
C28H35ClN6O3
Formula Weight
539.1
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 12 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS(pH 7.2) (1:2): 0.3 mg/mL
λmax
274 nm
SMILES
COC1=C(NC2=NC=C(Cl)C(N[C@@H]3[C@H](C4)C=C[C@H]4[C@@H]3C(N)=O)=N2)C=CC5=C1CC[C@@H](N6CCOCC6)CC5
InChi Code
InChI=1S/C28H35ClN6O3/c1-37-25-20-8-7-19(35-10-12-38-13-11-35)6-4-16(20)5-9-22(25)32-28-31-15-21(29)27(34-28)33-24-18-3-2-17(14-18)23(24)26(30)36/h2-3,5,9,15,17-19,23-24H,4,6-8,10-14H2,1H3,(H2,30,36)(H2,31,32,33,34)/t17-,18+,19+,23+,24-/m1/s1
InChi Key
LAJAFFLJAJMYLK-CVOKMOJFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18406-1 |
|---|---|
| Supplier Part Number | 18406-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1022958-60-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |