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Cayman LY404039
List Price
$159.00
Your Price
$159.00
Cayman LY404039 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-18408-10
MFG.PART:
18408-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
LY404039 is a potent agonist of metabotropic glutamate (mGlu) group II receptors mGluR2 and mGluR3 (Kis = 149 and 62 nM, respectively, for recombinant human isoforms).1 It displays 100-fold selectivity for mGluR2/3 over ionotropic glutamate receptors, glutamate transporters, and several other receptors targeted by known anxiolytic and antipsychotic medications.1 LY404039 inhibits the binding of domperidone (Item No. 18875) by 15.5% to dopamine D2 receptors (Kd = ~10 nM in vitro), indicating interaction with this receptor.2 LY404039 is orally bioavailable and demonstrates antipsychotic and anxiolytic efficacy in several animal models.3
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(1R,4S,5S,6S)
CAS Number
635318-11-5
Molecular Formula
C7H9NO6S
Formula Weight
235.2
Purity
≥95%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- PBS (pH 7.2): 0.5 mg/mL
SMILES
O=S1([C@]([C@@H]2C(O)=O)([H])[C@]2([H])[C@@](C(O)=O)(N)C1)=O
InChi Code
InChI=1S/C7H9NO6S/C8-7(6(11)12)1-15(13,14)4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1
InChi Key
AVDUGNCTZRCAHH-MDASVERJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18408-10 |
|---|---|
| Supplier Part Number | 18408-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 635318-11-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |