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Cayman GDC-0068
List Price $63.00 Your Price $63.00
Cayman GDC-0068 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-18412-1
MFG.PART: 18412-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in cell-free assays. It is 620-fold selective for Akt over protein kinase A and has been shown to block Akt signaling selectively in cultured tumor cell lines characterized by activated Akt, halting cell cycle progression and reducing cell viability. In multiple tumor xenograft models, oral administration of GDC-0068 at 100 mg/kg/day can lead to delayed tumor growth and regression.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(2S)-(4-chlorophenyl)-
CAS Number
1001264-89-6
Synonyms
- Ipatasertib
- RG-7440
Molecular Formula
C24H32ClN5O2
Formula Weight
458.0
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 25 mg/mL
- DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL
- DMSO: 15 mg/mL
- Ethanol: 20 mg/mL
λmax
258 nm
SMILES
ClC1=CC=C([C@H](C(N2CCN(C3=NC=NC4=C3[C@H](C)C[C@H]4O)CC2)=O)CNC(C)C)C=C1
InChi Code
InChI=1S/C24H32ClN5O2/c1-15(2)26-13-19(17-4-6-18(25)7-5-17)24(32)30-10-8-29(9-11-30)23-21-16(3)12-20(31)22(21)27-14-28-23/h4-7,14-16,19-20,26,31H,8-13H2,1-3H3/t16-,19-,20-/m1/s1
InChi Key
GRZXWCHAXNAUHY-NSISKUIASA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18412-1 |
|---|---|
| Supplier Part Number | 18412-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1001264-89-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |