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Cayman RP-8-pCPT-Cyclic GMPS (sodium salt)
List Price $307.00 Your Price $307.00
Cayman RP-8-pCPT-Cyclic GMPS (sodium salt) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-18445-1
MFG.PART: 18445-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
RP-8-pCPT-Cyclic GMPS is a stable, cell-permeable cGMP analog that competitively inhibits cGMP-dependent protein kinases (cGKs), including cGK Iα and cGK II (IC50s = 18.3 and 0.16 µM, respectively). The pCPT (p-chlorophenylthio) group at the 8-position of the purine increases both enzyme affinity and membrane permeability over related compounds. At 10 µM, it blocks the relaxation of rat tail arteries induced by the nitric oxide donor SIN-1 (Item No. ).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
8-[(4-chlorophenyl)thio]-
CAS Number
208445-07-2
Synonyms
- RP-8-pCPT-cGMPS
Molecular Formula
C16H14ClN5O6PS2 • Na
Formula Weight
525.9
Purity
≥99%
Formulation
A crystalline solid
Solubility
- Water: soluble
SMILES
O[C@H]1[C@H](N2C(SC3=CC=C(Cl)C=C3)=NC4=C2N=C(N)NC4=O)O[C@H]5[C@H]1O[P@@](OC5)([S-])=O.[Na+]
InChi Code
InChI=1S/C16H15ClN5O6PS2.Na/c17-6-1-3-7(4-2-6)31-16-19-9-12(20-15(18)21-13(9)24)22(16)14-10(23)11-8(27-14)5-26-29(25,30)28-11;/h1-4,8,10-11,14,23H,5H2,(H,25,30)(H3,18,20,21,24);/q;+1/p-1/t8-,10-,11-,14-,29-;/m1./s1
InChi Key
JERAACMSJYSCBY-TXBWCVORSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18445-1 |
|---|---|
| Supplier Part Number | 18445-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | Germany |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 208445-07-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |