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Cayman SBI-0206965
List Price $135.00 Your Price $135.00
Cayman SBI-0206965 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-18477-10
MFG.PART: 18477-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
ULK1 is a serine/threonine kinase that acts upstream of phosphatidylinositol 3-kinase (PI3K) to regulate the formation of autophagophores, the precursors of autophagosomes, in response to nutrient deprivation. It is activated by phosphorylation by AMPK and, in turn, phosphorylates and inhibits AMPK. SBI-0206965 is an inhibitor of ULK1 (IC50 = 108 nM) that is less effective against ULK2 (IC50 = 711 nM). It is selective for ULK1 and ULK2 over a panel of 456 additional kinases, showing activity against a few kinases in vitro but not in cells. SBI-0206965 suppresses autophagy induced by mTOR inhibition via AZD 8055 (Item No. ). It also blocks ULK1-dependent cell survival following nutrient deprivation.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[[5-bromo-2-
CAS Number
1884220-36-3
Molecular Formula
C21H21BrN4O5
Formula Weight
489.3
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL
- Ethanol: 1 mg/mL
λmax
202, 284 nm
SMILES
CNC(C(C=CC=C1)=C1OC2=C(Br)C=NC(NC3=CC(OC)=C(OC)C(OC)=C3)=N2)=O
InChi Code
InChI=1S/C21H21BrN4O5/c1-23-19(27)13-7-5-6-8-15(13)31-20-14(22)11-24-21(26-20)25-12-9-16(28-2)18(30-4)17(10-12)29-3/h5-11H,1-4H3,(H,23,27)(H,24,25,26)
InChi Key
NEXGBSJERNQRSV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18477-10 |
|---|---|
| Supplier Part Number | 18477-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1884220-36-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |