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Cayman S0859
List Price $36.00 Your Price $36.00
Cayman S0859 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-18497-1
MFG.PART: 18497-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
S0859 is an N-cyanosulphonamide that blocks the sodium/bicarbonate cotransporter (NBC, also known as SLC4A7), which regulates intracellular pH, particularly in myocytes. It inhibits intracellular pH recovery in myocytes with a Ki value of 1.7 µM, with full inhibition occurring at ~30 µM. S0859 does not affect other exchange proteins or enzymes that might regulate intracellular pH. It prevents changes in pH associated with depolarization and hyperpolarization of ventricular myocytes from rabbit, rat, and guinea pig. S0859 has also been used to study the role of NBC in coronary endothelial cells, cancer cells, embryonic kidney cells, and neutrophils.,,,
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-chloro-
CAS Number
1019331-10-2
Molecular Formula
C29H24ClN3O3S
Formula Weight
530.0
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 50 mg/mL
- DMSO: 30 mg/mL
- Ethanol: 50 mg/mL
- PBS (pH 7.2): 10 mg/mL
SMILES
CC(C=C1)=CC=C1CN(C(C2=CC=CC=C2Cl)=O)CC(C=C3)=CC=C3C(C=CC=C4)=C4S(NC#N)(=O)=O
InChi Code
InChI=1S/C29H24ClN3O3S/c1-21-10-12-22(13-11-21)18-33(29(34)26-7-2-4-8-27(26)30)19-23-14-16-24(17-15-23)25-6-3-5-9-28(25)37(35,36)32-20-31/h2-17,32H,18-19H2,1H3
InChi Key
ITDBPOSLOROLMT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-18497-1 |
|---|---|
| Supplier Part Number | 18497-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1019331-10-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |