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Cayman 4-amino-1,8-Naphthalimide
List Price $376.00 Your Price $376.00
Cayman 4-amino-1,8-Naphthalimide - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-18509-100
MFG.PART: 18509-100
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species.1,2 4-amino-1,8-Naphthalimide (4-ANI) is an inhibitor of PARP (IC50 = 180 nM).3 It blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of γ-radiation, although it is not cytotoxic in the absence of radiation.4 4-ANI is used to study the role of PARP activity in various cell systems.5,6,7
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6-amino-1H-benz
CAS Number
1742-95-6
Synonyms
- 4-Aminonaphthalimide
- 4-ANI
Molecular Formula
C12H8N2O2
Formula Weight
212.2
Purity
≥95%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 0.3 mg/mL
- DMSO: 1 mg/mL
λmax
227, 252, 275, 435 nm
SMILES
NC1=C2C(C3=CC=C2)=C(C=C1)C(NC3=O)=O
InChi Code
InChI=1S/C12H8N2O2/c13-9-5-4-8-10-6(9)2-1-3-7(10)11(15)14-12(8)16/h1-5H,13H2,(H,14,15,16)
InChi Key
SSMIFVHARFVINF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18509-100 |
|---|---|
| Supplier Part Number | 18509-100 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1742-95-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |