We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Cayman mL-348
List Price
$36.00
Your Price
$36.00
Cayman mL-348 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-18523-1
MFG.PART:
18523-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Lysophospholipase 1 (LYPLA1) is a protein palmitoyl thioesterase responsible for depalmitoylation of the oncogene HRas., Palmitoylation of such oncogenes is thought to be required for trafficking and malignant transformation, making LYPLA1 a target for downregulating oncogenic signaling., mL-348 is a reversible LYPLA1 inhibitor with an IC50 value of 210 nM. It is 14-fold selective for LYPLA1 over LYPLA2 (IC50 = >3,000) and demonstrates little activity against a panel of more than 20 other serine hydrolases (IC50s = >10,000).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[2-chloro-5-
CAS Number
899713-86-1
Synonyms
- CID-3238952
- SID 160654487
Molecular Formula
C18H17ClF3N3O3
Formula Weight
415.8
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- Ethanol: 20 mg/mL
- PBS (pH 7.2): 10 mg/mL
λmax
248 nm
SMILES
O=C(NC1=C(Cl)C=CC(C(F)(F)F)=C1)CN2CCN(C(C3=CC=CO3)=O)CC2
InChi Code
InChI=1S/C18H17ClF3N3O3/c19-13-4-3-12(18(20,21)22)10-14(13)23-16(26)11-24-5-7-25(8-6-24)17(27)15-2-1-9-28-15/h1-4,9-10H,5-8,11H2,(H,23,26)
InChi Key
OXKNHBBDOIMFFQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18523-1 |
|---|---|
| Supplier Part Number | 18523-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 899713-86-1 |
| Energy Star | No |
| Green | No |
| Controlled | N |