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Cayman GSK503
List Price $154.00 Your Price $154.00
Cayman GSK503 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-18531-10
MFG.PART: 18531-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
The lysine methyltransferase EZH2 (KMT6), part of the polycomb repressive complex 2, catalyzes trimethylation of lysine 27 on histone H3 (H3K27me3) and is involved in proliferation and aggressive cell growth associated with neoplastic cells. GSK503 is an inhibitor of EZH2 that prevents the methyltransferase activity of wild-type and mutant EZH2 with similar potency (apparent Ki = 3-27 nM).1 It is more than 200-fold selective for EZH2 over EZH1 and more than 4,000-fold selective over other histone methyltransferases. GSK503 displays favorable pharmacokinetics in mice. It prevents germinal center formation and hyperplasia that is relevant to lymphoma generation and inhibits growth and metastasis of cutaneous melanomas in mice.1,2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[(1,2-dihydro-
CAS Number
1346572-63-1
Molecular Formula
C31H38N6O2
Formula Weight
526.7
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 25 mg/mL
- DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL
- DMSO: 15 mg/mL
- Ethanol: 2 mg/mL
λmax
235, 282 nm
SMILES
CN1CCN(C2=NC=C(C3=CC(C(NCC4=C(C)C=C(C)NC4=O)=O)=C(C(C)=CN5C(C)C)C5=C3)C=C2)CC1
InChi Code
InChI=1S/C31H38N6O2/c1-19(2)37-18-21(4)29-25(30(38)33-17-26-20(3)13-22(5)34-31(26)39)14-24(15-27(29)37)23-7-8-28(32-16-23)36-11-9-35(6)10-12-36/h7-8,13-16,18-19H,9-12,17H2,1-6H3,(H,33,38)(H,34,39)
InChi Key
HRDQQHUKUIKFHT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18531-10 |
|---|---|
| Supplier Part Number | 18531-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1346572-63-1 |
| Energy Star | No |
| Green | No |
| Controlled | N |