Cayman CGP 35348

The amino acid γ-aminobutyric acid (GABA) is an inhibitory neurotransmitter that acts through two families of heteromeric ligand-gated ion channels, GABA_A and GABA_C, and a g protein-coupled receptor, GABA_B. CGP 35348 is a selective, brain-accessible GABA_B receptor antagonist (IC₅₀ = 34 µM).¹ It blocks the action of the GABA_B-selective agonist baclofen (Item No. 18600) at postsynaptic sites but not at presynaptic receptors.^1,2 CGP 35348 prevents baclofen-induced antinociception and muscle relaxation in mice and rats.³ It is commonly used to investigate the role of GABA_B activation in neurological signaling.^4,5,6

WARNING This product is not for human or veterinary use.