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Cayman BAY-678
List Price $183.00 Your Price $183.00
Cayman BAY-678 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-18615-10
MFG.PART: 18615-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
BAY-678 is a cell permeable inhibitor of human neutrophil elastase. This product, the (R) isomer, inhibits human neutrophil elastase with an in vitro IC50 value of 20 nM.1,2 BAY-678 displays greater than 2,000-fold selectivity for neutrophil elastase over a panel of 21 serine proteases, and there is no significant inhibition against 7 serine/threonine kinases and 64 pharmacologically relevant proteins.1,2 It has a favorable pharmacokinetic profile and demonstrates efficacy in acute in vivo models, including protease-induced acute lung injury in mice.1,2 See the Structural Genomics Consortium (SGC) website for more information.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-[(4R)-5-
CAS Number
675103-36-3
Molecular Formula
C20H15F3N4O2
Formula Weight
400.4
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:2): 0.33 mg/mL
λmax
228, 277 nm
SMILES
O=C1N(C2=CC(C(F)(F)F)=CC=C2)C(C)=C(C(C)=O)[C@@H](C3=CN=C(C#N)C=C3)N1
InChi Code
InChI=1S/C20H15F3N4O2/c1-11-17(12(2)28)18(13-6-7-15(9-24)25-10-13)26-19(29)27(11)16-5-3-4-14(8-16)20(21,22)23/h3-8,10,18H,1-2H3,(H,26,29)/t18-/m1/s1
InChi Key
PGIVGIFOWOVINL-GOSISDBHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18615-10 |
|---|---|
| Supplier Part Number | 18615-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 675103-36-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |