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Cayman Mitotane
List Price $110.00 Your Price $110.00
Cayman Mitotane - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-18651-500
MFG.PART: 18651-500
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Mitotane is an inhibitor of steroidogenesis.1 It decreases secretion of cortisol (Item No. 20739) and 17-hydroxy progesterone (Item No. 33154) from H295R adrenocortical carcinoma cells when used at a concentration of 50 µM. Mitotane also inhibits mitochondrial complex IV, also known as cytochrome c oxidase, activity in H295R cells (IC50 = 58 µM). It inhibits steroid production induced by adrenocorticotropic hormone (ACTH) and is cytotoxic to zona fasciculata and zona reticularis, but not zona glomerulosa, adrenal cortex cells in dogs when administered at a dose of 60 mg/kg.2 Formulations containing mitotane have been used in the treatment of adrenocortical carcinoma.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1-chloro-2-
CAS Number
53-19-0
Synonyms
- o,p-DDD
- 1,1-Dichlorodiphenildichloroethane
- NSC 38721
Molecular Formula
C14H10Cl4
Formula Weight
320.0
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:2): 0.33 mg/mL
- Ethanol: 20 mg/mL
λmax
229 nm
SMILES
ClC1=CC=C(C(C(Cl)Cl)C2=CC=CC=C2Cl)C=C1
InChi Code
InChI=1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H
InChi Key
JWBOIMRXGHLCPP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18651-500 |
|---|---|
| Supplier Part Number | 18651-500 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 53-19-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |