Cayman Ch 55

Ch 55 is a synthetic analog of retinoic acid (Item No. ) that binds to retinoic acid receptors with similar efficiency as retinoic acid (K_is in the nM range) yet does not display affinity for cellular retinoic acid-binding protein (K_i = 540 µM). Ch 55 has been shown to inhibit squamous cell differentiation of rabbit tracheal epithelial cells by inhibiting type I transglutaminase activity (EC₅₀ = 0.02 nM) and increasing cholesterol sulfate levels (EC₅₀ = 0.03 nM). In contrast, it has also been shown to induce differentiation of embryonic carcinoma F9 cells and melanoma S91 cells (EC₅₀s = 0.26 and 0.5 nM, respectively), as well as inhibit the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC₅₀ = 1 nM).

WARNING This product is not for human or veterinary use.