Cayman Mebendazole

Mebendazole is an inhibitor of microtubule polymerization and an anthelmintic.¹ It reduces microtubule polymerization in a cell-free assay when used at a concentration of 10 µM. Mebendazole reduces container attachment, a measure of viability, by g. duodenalis with a half-maximal inhibition of binding (IB₅₀) value of 190 nM.² It reduces the proliferation of SK-MEL-19 and M14 melanoma cell lines (IC₅₀s = 300 and 320 µM, respectively) and induces apoptosis and poly(ADP-ribose) polymerase (PARP) cleavage in SK-MEL-19 and M14 cells, but not melanocytes, when used at a concentration of 1 µM.³ It decreases oxidative stress-induced cell death in primary mouse cortical neurons in a concentration-dependent manner.¹ In vivo, mebendazole (800 µg/animal every other day) decreases tumor volume, weight, hemoglobin levels, and vascularization in an H460 lung cancer mouse xenograft model.⁴ Mebendazole (8.8 mg/kg) eradicates S. vulgaris, S. edentates, and S. equinus worm burden in infected ponies.⁵ Formulations containing mebendazole have been used in the treatment of helminth gastrointestinal infections.

WARNING This product is not for human or veterinary use.