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Cayman PF-9184
List Price $354.00 Your Price $354.00
Cayman PF-9184 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-18904-25
MFG.PART: 18904-25
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Microsomal prostaglandin E synthase-1 (mPGES-1) converts the COX product prostaglandin H2 (PGH2; Item No. 17020) into the biologically active PGE2 (Item No. 14010).1 Like COX-2, the expression of mPGES-1 is induced in response to pro-inflammatory mediators, including LPS, IL-1β, and TNF-α.2 PF-9184 is a potent inhibitor of mPGES-1 (IC50 = 16.5 nM for recombinant human enzyme).3 It displays at least 6,500-fold selectivity for mPGES-1 over COX-1 and COX-2. PF-9184 blocks the synthesis of PGE2 in LPS-treated human whole blood and in IL-1β-stimulated fibroblasts (IC50s = 0.4-5 µM).4,5
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-(3,4-
CAS Number
1221971-47-6
Molecular Formula
C21H14Cl2N2O4S
Formula Weight
461.3
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 20 mg/mL
- DMSO: 15 mg/mL
λmax
269, 335 nm
SMILES
OC1=C(C(NC2=CC=C(C3=CC=C(Cl)C(Cl)=C3)C=C2)=O)NS(C4=CC=CC=C41)(=O)=O
InChi Code
InChI=1S/C21H14Cl2N2O4S/c22-16-10-7-13(11-17(16)23)12-5-8-14(9-6-12)24-21(27)19-20(26)15-3-1-2-4-18(15)30(28,29)25-19/h1-11,25-26H,(H,24,27)
InChi Key
VGACSWBJQLLJFB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-18904-25 |
|---|---|
| Supplier Part Number | 18904-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1221971-47-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |