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Cayman FzM1
List Price $41.00 Your Price $41.00
Cayman FzM1 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-19074-500
MFG.PART: 19074-500
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis.1,2,3 Wnt proteins initiate cell signaling by binding Frizzled (Fz) receptors, a family of g protein-coupled receptors. FzM1 is an allosteric ligand of Fz4.4 At 10 µM, it inhibits nuclear translocation of β-catenin in U87MG glioma cells treated with lithium chloride, a GSK3 inhibitor that enhances the Wnt canonical signaling pathway.4 FzM1 impairs the ability of U87MG cells to form neurospheres in culture and stimulates the differentiation of Caco-2 epithelial colorectal adenocarcinoma cells.4
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[3-
CAS Number
1680196-54-6
Synonyms
- Frizzled M1
Molecular Formula
C21H16N2O2S
Formula Weight
360.4
Purity
≥95%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 12 mg/mL
- DMF:PBS (pH 7.2)(1:3): 0.2 mg/mL
- DMSO: 10 mg/mL
λmax
211, 233, 261, 284 nm
SMILES
O=C(NC1=CC(O)=CC(C2=CC=CS2)=C1)NC3=CC4=CC=CC=C4C=C3
InChi Code
InChI=1S/C21H16N2O2S/c24-19-12-16(20-6-3-9-26-20)11-18(13-19)23-21(25)22-17-8-7-14-4-1-2-5-15(14)10-17/h1-13,24H,(H2,22,23,25)
InChi Key
OBTSACXGWYGCPK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-19074-500 |
|---|---|
| Supplier Part Number | 19074-500 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1680196-54-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |