Cayman NF-κB Activation Inhibitor III

NF-κB activation inhibitor III is an inhibitor of NF-κB activation. NF-κB activation inhibitor III (20 µM) inhibits TNF-α-induced NF-κB activation in HT-1080 fibrosarcoma cells. NF-κB activation inhibitor III inhibits TNF-α-induced expression of the gene encoding matrix metalloproteinase-9 (MMP-9) in HT-1080 cells in a concentration-dependent manner and decreases TNF-α-induced migration of HT-1080 cells. It inhibits IL-6 release induced by TNF-α from primary rat brain pericytes when used at concentrations of 1, 5, and 10 µM. NF-κB activation inhibitor III (5 µM) increases IL-8 secretion in HT-29 and Caco-2 colon cancer cells when used in combination with glyoxal.

WARNING This product is not for human or veterinary use.