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Cayman CBL0137
List Price
$52.00
Your Price
$52.00
Cayman CBL0137 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-19110-1
MFG.PART:
19110-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
CBL0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 of 0.47 µM. It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-κB and promoting cancer cell death. CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates efficacy of gemcitabine (Item No. ) in preclinical models of pancreatic cancer.,
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1,1-[9-[2-[(1-
CAS Number
1197996-80-7
Synonyms
- CBLC137
- Curaxin 137
Molecular Formula
C21H24N2O2
Formula Weight
336.4
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 5 mg/mL
- DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL
- DMSO: 5 mg/mL
- Ethanol: 2 mg/mL
λmax
259, 291, 332 nm
SMILES
CC(C1=CC=C2C(C(C=C(C(C)=O)C=C3)=C3N2CCNC(C)C)=C1)=O
InChi Code
InChI=1S/C21H24N2O2/c1-13(2)22-9-10-23-20-7-5-16(14(3)24)11-18(20)19-12-17(15(4)25)6-8-21(19)23/h5-8,11-13,22H,9-10H2,1-4H3
InChi Key
JKCSODVERGVDLT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-19110-1 |
|---|---|
| Supplier Part Number | 19110-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1197996-80-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |