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Cayman CPI-360
List Price $75.00 Your Price $75.00
Cayman CPI-360 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-19125-1
MFG.PART: 19125-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
CPI-360 is a selective EZH2 inhibitor with IC50 values of 0.5 and 2.5 nM for wild-type EZH2 and Y641N mutant EZH2, respectively. It decreases cellular levels of H3K27me3 and H3K27me2 (EC50s = 56 and 65 nM, respectively), triggering cell cycle arrest and ultimately resulting in apoptosis in a large panel of non-Hodgkin’s lymphoma (NHL) cell lines. Twice daily, subcutaneous administration of 200 mg/kg of CPI-360 reduced tumor growth of KARPAS-422 xenografts in mice.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[(1,2-
CAS Number
1802175-06-9
Molecular Formula
C25H31N3O4
Formula Weight
437.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 10 mg/mL
- DMSO: 25 mg/mL
- Ethanol: 30 mg/mL
- Ethanol:PBS (pH7.2) (1:7): 0.12 mg/mL
λmax
212, 292 nm
SMILES
CC(N1)=CC(OC)=C(CNC(C2=C(C)N([C@H](C)C3CCOCC3)C4=C2C=CC=C4)=O)C1=O
InChi Code
InChI=1S/C25H31N3O4/c1-15-13-22(31-4)20(24(29)27-15)14-26-25(30)23-17(3)28(21-8-6-5-7-19(21)23)16(2)18-9-11-32-12-10-18/h5-8,13,16,18H,9-12,14H2,1-4H3,(H,26,30)(H,27,29)/t16-/m1/s1
InChi Key
PFPSFENQCNMITC-MRXNPFEDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-19125-1 |
|---|---|
| Supplier Part Number | 19125-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1802175-06-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |