We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Cayman Esi-09; Purity- Greater Than Or Equal To 95%; Size- 5 Mg;
List Price
$93.00
Your Price
$93.00
Cayman Esi-09; Purity- Greater Than Or Equal To 95%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-19130-5
MFG.PART:
19130-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
AZD 3839 is an inhibitor of beta-secretase 1 (BACE1)., It selectively binds to BACE1 over BACE2 (Kis = 26.1 and 372.4 nM, respectively, for the human enzymes). It also inhibits human ether-a-go-go-related gene (hERG) potassium channels expressed in CHO cells (IC50 = 4.8 μM). AZD 3839 decreases amyloid-β (Aβ) secretion from mouse Neuro2a neuroblastoma cells and primary neurons (IC50s = 32.2 and 50.9 nM, respectively). It dose- and time-dependently decreases Aβ levels in the plasma and brain of mice and guinea pigs. AZD 3839 also decreases Aβ in the cerebrospinal fluid (CSF) of cynomolgus monkeys when administered at a dose of 20 μmol/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(1S)-1-[2-
CAS Number
1227163-84-9
Molecular Formula
C24H16F3N5
Formula Weight
431.4
Purity
≥98%
Formulation
A solid
Solubility
- DMF: 2 mg/ml
- DMSO: 30 mg/ml
- Ethanol: 30 mg/ml
- Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
SMILES
FC1=C(C(N)=N[C@@]2(C3=CC=CC(C4=CN=CN=C4)=C3)C5=CC(C(F)F)=NC=C5)C2=CC=C1
InChi Code
InChI=1S/C24H16F3N5/c25-19-6-2-5-18-21(19)23(28)32-24(18,17-7-8-31-20(10-17)22(26)27)16-4-1-3-14(9-16)15-11-29-13-30-12-15/h1-13,22H,(H2,28,32)/t24-/m0/s1
InChi Key
MRXBCEQZNKUUIP-DEOSSOPVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-19130-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 19130-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 263707-16-0 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |