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Cayman SBC-115076
List Price $436.00 Your Price $436.00
Cayman SBC-115076 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-19134-25
MFG.PART: 19134-25
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Proprotein convertase subtilisin kexin 9 (PCSK9) is a member of the subtilisin serine protease family with important roles in lipoprotein metabolism.1 PCSK9 overexpression in wild-type mice doubles plasma total cholesterol, possibly through acceleration of degradation of the LDL receptor (LDLR).1,2 SBC-115076 is an inhibitor of PCSK9 action that blocks LDLR degradation in HEK293T cells expressing PCSK9.3 Through this mechanism, submicromolar concentrations of SBC-115076 increase the uptake of LDL by liver cells in vitro.3 SBC-115076 is effective in vivo, lowering cholesterol levels in mice that are fed a high fat diet.3
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1,5-dihydro-
CAS Number
489415-96-5
Molecular Formula
C31H33N3O5
Formula Weight
527.6
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 2 mg/mL
- DMSO: 5 mg/mL
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL
λmax
234, 320 nm
SMILES
CC1=CC(C(C(C(C2=CC=NC=C2)N3CCCN4CCOCC4)=C(O)C3=O)=O)=CC=C1OCC5=CC=CC=C5
InChi Code
InChI=1S/C31H33N3O5/c1-22-20-25(8-9-26(22)39-21-23-6-3-2-4-7-23)29(35)27-28(24-10-12-32-13-11-24)34(31(37)30(27)36)15-5-14-33-16-18-38-19-17-33/h2-4,6-13,20,28,36H,5,14-19,21H2,1H3
InChi Key
UNINQWCCZAGYSH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-19134-25 |
|---|---|
| Supplier Part Number | 19134-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 489415-96-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |