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Cayman EI1
List Price $235.00 Your Price $235.00
Cayman EI1 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-19146-10
MFG.PART: 19146-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
The lysine methyltransferase EZH2 (KMT6), part of polycomb repressive complex 2 (PRC2), catalyzes trimethylation of lysine 27 on histone H3 (H3K27) and is involved in proliferation and aggressive cell growth associated with neoplastic cells.1 EI1 is an EZH2 inhibitor that has activity against both wild-type and Y641F mutant EZH2 (IC50s = 15 and 13 nM, respectively).2 It displays 90-fold selectivity for EZH2 over EZH1 and >10,000-fold over other lysine methyltransferases. EI1 blocks cellular H3K27 methylation and activates PRC2-specific gene expression.2 Inhibition of EZH2 by EI1 in diffused large B cell lymphoma cells carrying Y641 mutations results in decreased proliferation, cell cycle arrest, and apoptosis.2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6-cyano-N-[(1,2-dihydro-
CAS Number
1418308-27-6
Molecular Formula
C23H26N4O2
Formula Weight
390.5
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 2 mg/mL
- DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL
- DMSO: 2 mg/mL
λmax
250, 309 nm
SMILES
O=C(NCC1=C(C)C=C(C)NC1=O)C2=CC(C#N)=CC3=C2C=CN3C(CC)CC
InChi Code
InChI=1S/C23H26N4O2/c1-5-17(6-2)27-8-7-18-19(10-16(12-24)11-21(18)27)22(28)25-13-20-14(3)9-15(4)26-23(20)29/h7-11,17H,5-6,13H2,1-4H3,(H,25,28)(H,26,29)
InChi Key
PFHDWRIVDDIFRP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-19146-10 |
|---|---|
| Supplier Part Number | 19146-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1418308-27-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |