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Cayman MK-5108
List Price $63.00 Your Price $63.00
Cayman MK-5108 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-19167-1
MFG.PART: 19167-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. MK-5108 is a potent inhibitor of Aurora A (IC50 = 0.064 nM). It less potently inhibits Aurora B and Aurora C (IC50s =14 and 12 nM, respectively). MK-5108 blocks cell cycle progression and induces apoptosis in a diverse range of human tumor types., It is effective in vivo, inhibiting the growth of xenograft tumors in mice.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
trans-4-(3-chloro-2-fluorophenoxy)-
CAS Number
1010085-13-8
Synonyms
- VX-689
Molecular Formula
C22H21ClFN3O3S
Formula Weight
461.9
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 5 mg/mL
- DMF:PBS (pH7.2) (1:30): 0.025 mg/mL
- DMSO: 2 mg/mL
λmax
278, 310 nm
SMILES
ClC1=C(F)C(O[C@@H]2CC[C@@](CC3=CC=CC(NC4=NC=CS4)=N3)(C(O)=O)CC2)=CC=C1
InChi Code
InChI=1S/C22H21ClFN3O3S/c23-16-4-2-5-17(19(16)24)30-15-7-9-22(10-8-15,20(28)29)13-14-3-1-6-18(26-14)27-21-25-11-12-31-21/h1-6,11-12,15H,7-10,13H2,(H,28,29)(H,25,26,27)/t15-,22-
InChi Key
LCVIRAZGMYMNNT-VVONHTQRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-19167-1 |
|---|---|
| Supplier Part Number | 19167-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1010085-13-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |