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Cayman Tanomastat
List Price $75.00 Your Price $75.00
Cayman Tanomastat - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-19258-1
MFG.PART: 19258-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Tanomastat is an inhibitor of matrix metalloproteinase-2 (MMP-2), MMP-3, and MMP-9 (Kis = 11, 143, and 301 nM, respectively). It is selective for MMP-2, -3, and -9 over MMP-1 and MMP-13 (Kis = 5,000 and 1,470 nM, respectively). Tanomastat (15 µM) inhibits VEGF- and FGF-induced tubule formation in human umbilical vein endothelial cells (HUVECs). It reduces tumor growth and the number of pulmonary metastases in an MDA-MB-435 orthotopic mouse model of breast cancer when administered at a dose of 100 mg/kg. Tanomastat (50 mg/kg) decreases disease severity in a rat model of adjuvant-induced arthritis.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-
CAS Number
179545-77-8
Synonyms
- BAY 12-9566
Molecular Formula
C23H19ClO3S
Formula Weight
410.9
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 25 mg/mL
- DMF:PBS (pH 7.2) (1:1): 0.5 mg/mL
- DMSO: 25 mg/mL
- Ethanol: 12 mg/mL
λmax
285 nm
SMILES
ClC1=CC=C(C2=CC=C(C(C[C@@H](C(O)=O)CSC3=CC=CC=C3)=O)C=C2)C=C1
InChi Code
InChI=1S/C23H19ClO3S/c24-20-12-10-17(11-13-20)16-6-8-18(9-7-16)22(25)14-19(23(26)27)15-28-21-4-2-1-3-5-21/h1-13,19H,14-15H2,(H,26,27)/t19-/m1/s1
InChi Key
JXAGDPXECXQWBC-LJQANCHMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-19258-1 |
|---|---|
| Supplier Part Number | 19258-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | Canada |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 179545-77-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |