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Cayman SR 0987
List Price
$30.00
Your Price
$30.00
Cayman SR 0987 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-19503-1
MFG.PART:
19503-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
SR 0987 is an agonist of the T cell-specific isoform of RORγ (RORγt, retinoic acid receptor-related orphan receptor-γt), inducing reporter gene expression with an EC50 value of ~800 nM. Stimulation of mouse EL4 T lymphocytes with SR 0987, following activation with PMA (Item No. ) and ionomycin (Item No. ), increases expression of the RORγt target IL-17, while expression of the programmed cell death protein PD-1 is decreased and granzyme B is unchanged. Decreased cell surface PD-1 protein, assessed by flow cytometry, is observed in a variety of T cells treated with SR 0987.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-
CAS Number
303126-97-8
Molecular Formula
C16H10ClF6NO2
Formula Weight
397.7
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/mL
- DMSO: 15 mg/mL
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL
- Ethanol: 30 mg/mL
λmax
255 nm
SMILES
ClC1=CC=CC=C1C(NC2=CC=C(C(C(F)(F)F)(C(F)(F)F)O)C=C2)=O
InChi Code
InChI=1S/C16H10ClF6NO2/c17-12-4-2-1-3-11(12)13(25)24-10-7-5-9(6-8-10)14(26,15(18,19)20)16(21,22)23/h1-8,26H,(H,24,25)
InChi Key
IZVBONMVWLTLNT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-19503-1 |
|---|---|
| Supplier Part Number | 19503-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 303126-97-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |